1. Spieltag
| Datum | Heim | | Auswärts | Erg. | Tipp | Res. | G | U | V | 1 | X | 2 |
| 14.08.2021 | Bonner SC | - | Rot-Weiss Essen | -:- | 0:2 | - | 7.97% | 17.79% | 74.24% | 12.55 | 5.62 | 1.35 |
| | SV Lippstadt 08 | - | SC Wiedenbrück | -:- | 0:1 | - | 23.52% | 24.57% | 51.91% | 4.25 | 4.07 | 1.93 |
| | FC Schalke 04 II | - | 1. FC Köln II | -:- | 1:2 | - | 29.67% | 24.38% | 45.95% | 3.37 | 4.10 | 2.18 |
| | Preußen Münster | - | Alemannia Aachen | -:- | 2:0 | - | 60.46% | 21.71% | 17.83% | 1.65 | 4.61 | 5.61 |
| | VfB Homberg | - | Bor. Mönchengladbach II | -:- | 0:1 | - | 14.75% | 22.81% | 62.44% | 6.78 | 4.38 | 1.60 |
| | Fortuna Düsseldorf II | - | Sportfreunde Lotte | -:- | 1:0 | - | 43.70% | 25.62% | 30.67% | 2.29 | 3.90 | 3.26 |
| | SC Fortuna Köln | - | FC Wegberg-Beeck | -:- | 1:0 | - | 59.49% | 24.49% | 16.02% | 1.68 | 4.08 | 6.24 |
| | Rot-Weiß Oberhausen | - | SV Rödinghausen | -:- | 1:2 | - | 37.63% | 24.59% | 37.78% | 2.66 | 4.07 | 2.65 |
| | SV Straelen | - | Rot Weiss Ahlen | -:- | 1:0 | - | 39.24% | 28.16% | 32.60% | 2.55 | 3.55 | 3.07 |
Ergebnisse und Prognosen für alle Spieltage der Regional Liga West.
