22. Spieltag
| Datum | Heim | | Auswärts | Erg. | Tipp | Res. | G | U | V | 1 | X | 2 |
| 22.01.2022 14:00 | SV Straelen | - | Bonner SC | -:- | 1:0 | - | 46.91% | 27.10% | 25.99% | 2.13 | 3.69 | 3.85 |
| | Alemannia Aachen | - | SV Lippstadt 08 | -:- | 1:0 | - | 38.95% | 27.15% | 33.90% | 2.57 | 3.68 | 2.95 |
| | Bor. Mönchengladbach II | - | FC Schalke 04 II | -:- | 1:0 | - | 47.90% | 25.64% | 26.46% | 2.09 | 3.90 | 3.78 |
| | Sportfreunde Lotte | - | Preußen Münster | -:- | 0:2 | - | 17.51% | 21.69% | 60.80% | 5.71 | 4.61 | 1.64 |
| | FC Wegberg-Beeck | - | VfB Homberg | -:- | 1:0 | - | 55.23% | 28.35% | 16.41% | 1.81 | 3.53 | 6.09 |
| | SV Rödinghausen | - | Fortuna Düsseldorf II | -:- | 2:1 | - | 51.56% | 24.22% | 24.22% | 1.94 | 4.13 | 4.13 |
| | Rot Weiss Ahlen | - | SC Fortuna Köln | -:- | 0:1 | - | 26.41% | 24.97% | 48.62% | 3.79 | 4.00 | 2.06 |
| | SC Wiedenbrück | - | KFC Uerdingen 05 | -:- | 2:0 | - | 87.22% | 11.68% | 1.10% | 1.15 | 8.56 | 90.89 |
| 22.01.2022 15:30 | 1. FC Köln II | - | Rot-Weiß Oberhausen | -:- | 2:1 | - | 38.69% | 24.58% | 36.72% | 2.58 | 4.07 | 2.72 |
| 23.01.2022 14:00 | Rot-Weiss Essen | - | Wuppertaler SV | -:- | 2:1 | - | 56.39% | 21.87% | 21.74% | 1.77 | 4.57 | 4.60 |
Ergebnisse und Prognosen für alle Spieltage der Regional Liga West.
