21. Spieltag
| Datum | Heim | | Auswärts | Erg. | Tipp | Res. | G | U | V | 1 | X | 2 |
| 14.01.2022 19:00 | TSV Havelse | - | MSV Duisburg | -:- | 0:1 | - | 20.50% | 27.18% | 52.32% | 4.88 | 3.68 | 1.91 |
| 15.01.2022 14:00 | Hallescher FC | - | Türkgücü München | -:- | 1:0 | - | 42.96% | 26.35% | 30.69% | 2.33 | 3.79 | 3.26 |
| | 1.FC Kaiserslautern | - | SV Meppen | -:- | 1:0 | - | 49.64% | 25.94% | 24.42% | 2.01 | 3.86 | 4.09 |
| | FSV Zwickau | - | FC Viktoria Köln | -:- | 1:0 | - | 46.14% | 26.03% | 27.83% | 2.17 | 3.84 | 3.59 |
| | SC Freiburg II | - | 1.FC Magdeburg | -:- | 0:1 | - | 21.17% | 24.70% | 54.13% | 4.72 | 4.05 | 1.85 |
| | VfL Osnabrück | - | 1.FC Saarbrücken | -:- | 1:0 | - | 37.72% | 27.94% | 34.33% | 2.65 | 3.58 | 2.91 |
| | TSV 1860 München | - | SV Wehen Wiesbaden | -:- | 2:1 | - | 46.54% | 24.42% | 29.04% | 2.15 | 4.09 | 3.44 |
| 16.01.2022 13:00 | SC Verl | - | Würzburger Kickers | -:- | 1:0 | - | 44.75% | 27.60% | 27.65% | 2.23 | 3.62 | 3.62 |
| 16.01.2022 14:00 | FC Viktoria 1889 Berlin | - | Eintracht Braunschweig | -:- | 1:2 | - | 31.85% | 24.76% | 43.39% | 3.14 | 4.04 | 2.30 |
| 17.01.2022 19:00 | SV Waldhof Mannheim | - | Borussia Dortmund II | -:- | 1:2 | - | 37.77% | 24.38% | 37.85% | 2.65 | 4.10 | 2.64 |
Ergebnisse und Prognosen für alle Spieltage der 3. Liga.
